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However, these emerging markers are still in the basic research stage, lacking large samples to validate their clinical sensitivity, specificity and predictive value, and the refinement of telomere length shortening measurement to the extent that it is substantially associated with the developmental potential of the embryo has yet to be thoroughly investigated

We further evaluated whether the administration of mitapivat might synergize with the beneficial effect of splenectomy in 4.2 / mice

153 As a compensatory mechanism, IAPP may activate HIF-1/6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) to protect against oligomer toxicity, thus delaying the loss of cells but at the cost of impairing cell function