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Abbreviations TEs: trace elements HIV: human immunodeficiency virus ART: antiretroviral therapy PLHIV: people living with HIV DNA: deoxyribonucleic acid RNA: ribonucleic acid CD4: cluster of differentiation 4 CD8: cluster of differentiation 8 MHC: major histocompatibility complex IL-1: interleukin 1 IL-2: interleukin 2 Th1: type 1 T helper Fe: iron Cu: copper Mn: manganese Zn: zinc Se: selenium Mg: magnesium Ca: calcium K: potassium Cr: chromium NRTIs: nucleoside/nucleotide reverse transcriptase inhibitors PIs: protease inhibitors NNRTIs: non-nucleoside reverse transcriptase inhibitors INSTIs: integrase strand transfer inhibitors LDL: low-density lipoprotein HDL: high-density lipoprotein VLDL: very low-density lipoprotein CVD: cardiovascular disease AMI: acute myocardial infarction References Lu DY et al (2018) HAART in HIV/AIDS treatments: future trends

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Notably, the addition of carnitine or knockdown of TMLHE did not have marked effects on histone methylation (Extended Data Fig

MOSTI eScience Fund (02-02-10-SF0215) awarded to BG, and University of Malaya Research Grants PG136-2016A and PG082-2015B awarded to K-GC