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Oxidative stress induces c-Jun NH 2 -terminal kinase (JNK) activation, which would further promote mitochondrial dysfunction and mitochondrial permeability transition, amplify oxidative stress and lead to sustained JNK activation and ultimately cause cell death

The role of resveratrol in diabetes and obesity associated with insulin resistance

NICE guidance emphasises that weight loss (if overweight), increased physical activity, and dietary improvements remain the cornerstone of NAFLD management

According to emerging evidence from molecular studies, the tumor microenvironment uses key paracrine factors such as insulin-like growth factor 1 (IGF-1) to fuel tumorigenesis (13)