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Moreover, we selected 5 mg/kg LicoA for the subsequent verification after the preliminary experiments, this dosage selection aligns with findings reported in a previous study ( Renal tubular epithelial cell (RTEC) injury and death are central to the pathogenesis and progression of CKD (Zhao et al., 2023)

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Lobaccaro JM, Lumbroso S, Belon C, Galtier-Dereure F, Bringer J, Lesimple T, Heron JF, Pujol H, Sultan C

This article was financially supported by National Institutes of Health Public Health Service grants R01 HL144790, R01 HL151493, R01 AI145813, R01 AI169687, R01 HL151769, and R01 HL159804 (OA)