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These compounds are generated during thermal processing of foods and are present in high levels in processed and cooked foodstuffs, especially those subjected to extensively heat treatments (e.g., grilled meats, fried foods and baked goods) 14,15

Thalidomide, as a drug capable of inhibiting TNF- protein synthesis, effectively slows down the progression of many cancers, including multiple myeloma, by blocking the synthesis of several growth factors, including VEGF, basic fibroblast growth factor, and hepatocyte growth factor, as well as inhibiting the synthesis of tumor deoxyribonucleic acid (DNA) (258, 259)

TCO-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups

doi: 10.1016/j.ijpharm.2020.119482 [DOI] [PubMed] [Google Scholar] 125.Shanmugam T, Joshi N, Kaviratna A, et al