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In addition, studies have shown that propionic acid promotes apoptosis of CRC cells through multiple mechanisms, including mitochondrial dysfunction, release of apoptosis-inducing factors, activation of caspase-3, down-regulation of PRMT1, and up-regulation of TNFAIP1 (Ryu et al., 2019

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effects were relatively similar in head-to-head comparisons, and small variations were noted in studies using ALC in combination and comparing it to the same drug