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Although B12 deficiency is not a direct biomarker of cancer, some types, such as prostate cancer, are found to be associated with low levels of Vitamin B12 in the body

Additionally, for tumors with highly immunosuppressive TMEs, single-agent ICB therapy may be insufficient, necessitating combination strategies with other treatment modalities

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The proration factor is equal to the ratio of the ACO's average assigned beneficiary person years for the 2 performance years that constitute BY1 and BY2 for the ACO's current agreement period (regardless of whether these performance years occurred over one or multiple prior agreement periods) and the ACO's average assigned beneficiary person years in BY1 and BY2 for the ACO's current agreement period calculated using the ACO's certified ACO participant list and assignment methodology for a given performance year within the current agreement period, capped at one