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van den Engel-Hoek L, de Groot IJM, Sie LT, van Bruggen HW, de Groot SAF, Erasmus CE, et al

This distinction matters because exogenous GH administration carries a different risk profile than peptide-stimulated endogenous release

In contrast, the detrimental effect of mitophagy mostly occurs in scenarios of excessive activation or abnormal regulation: when cells encounter sustained and severe pathological stress (such as severe ischemia and severe inflammation), mitophagy is abnormally activated, which excessively degrades functionally normal mitochondria, leading to disorders of cellular energy metabolism, insufficient ATP synthesis, and simultaneous disruption of the normal proliferation and renewal balance of mitochondria in cells

Methodologies for simulation of gastrointestinal digestion of different controlled delivery systems and further uptake of encapsulated bioactive compounds