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Granulosa cells (both cumulus and granulosa cells) express high amounts of NAT and ASMT that help in the production of melatonin, and also receptors MT1 and MT2, which help in the binding of melatonin (185)

Typical oral dosages range 250500 mg daily for general antioxidant support, though bioavailability is limited

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They're the leading cause of illness and death ( HTN is the primary cause of cardiovascular (CV) and kidney diseases, but diabetes mellitus (DM), smoking, and DL are also significant risk factors ( Metabolic syndrome (MS), characterized by a cluster of conditions like impaired glucose tolerance (GT), DL, obesity, and HTN, is a major risk factor for CVDs