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The U-87 MG cells were cultured in cisplatin-containing media, at an initial concentration of 1/10 the half maximal inhibitory concentration (IC50), and the cisplatin concentration was increased gradually with continuous culture

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The increase of the probiotic population in the intestine following GTE supplementation has been shown in animal and human studies (Reference Axling, Olsson and Xu118,Reference Jin, Touyama and Hisada119) , demonstrating its possible effects on changing intestinal microbiota correlated with body fatness (Reference Remely, Tesar and Hippe120)

Mouse primary hepatocytes were cultured in DMEM solution containing 10% FBS at 37 on collagen -coated plates