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Description

Vitamin B12 has no established Tolerable Upper Intake Level because of its low toxicity potential

(1) The Rebate Report will include the information specified in paragraph (b)(1) of this section, with the inclusion of any revisions to such information resulting from CMS' review of a Suggestion of Error as set forth in 427.503, if applicable, and any CMS-determined recalculations from paragraph (d)(2) of this section

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They work by stimulating alpha-2 receptors in the brain, which reduce sympathetic outflow and norepinephrine release, thereby decreasing sympathetic activity and leading to effects such as reduced blood pressure, decreased heart rate, and alleviated withdrawal symptoms (92)