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EGFRvIII, expressed heterogeneously in approximately one-third of GBM patients, is absent in normal tissues and serves as an independent adverse prognostic marker, presenting a crucial target for antitumor immunotherapy [645]

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Overman MJ, Ferrarotto R, Raghav K, George B, Qiao W, Machado KK, Saltz LB, Mazard T, Vauthey JN, Hoff PM, Hobbs B, Loyer EM, Kopetz S

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In cases of acute DQ toxicity, it can exert severe toxic effects on the central nervous system, leading to symptoms resembling PD [55]

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