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The reaction can be important in pathological processes because DNA and other macromolecules contain nucleophiles, and ,-conjugated carbonyls are major products of lipid peroxidation of polyunsaturated fatty acids

The overall structure was manually fitted to the map using UCSF Chimera 71 and subjected to real space refinement using PHENIX with secondary structure, rotamer, Ramachandran, and noncrystallographic symmetry (NCS) restraints 67

Loss of deubiquitinase USP1 blocks pancreatic -cell apoptosis by inhibiting DNA damage response

Abstract The distinctive colour of brown adipose tissue (BAT) is attributed to its high content of haem-rich mitochondria