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Infection regulates pro-resolving mediators that lower antibiotic requirements

In C57BL/6 mice that were transplanted with a skin graft from Balb/C donors, CF extract significantly prolonged skin allograft survival synergistically by suppressing Th1 response, promoting regulatory T cell generation, and enhancing its suppressive function [59]

Some potential side effects of milk thistle include: Stomach problems (such as stomach ache, gas, bloating) Rashes Heartburn Sexual dysfunction (in extreme cases) Headaches Weakness However milk thistle is considered to be safe in doses of up to 420mg per day, so overdosing on it will be quite a difficult thing to do