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More particularly, a strong activation of PKC in the endothelium of diabetic patients is observed in the increased generation of ROS and microvascular OS (Nuez-Musa, 2024), and vasoconstriction potentiates and insulin signaling peripherally impairs (Robson et al., 2018)

There is a need for precision diagnostics that reflect all relevant symptoms, are more effective at predicting prognosis including for fertility and cardiovascular risks, and potentially indicate physiological pathways relevant to the syndrome

Association of MTHFR C677T gene polymorphism with metabolic syndrome in a Chinese population: A case-control study