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Table 4: Annual and 5-Year Budget Impact

Another important question is the nature of administrated vitamin B12in some studies [41], a difference in the effect was noted between the food-administrated cobalamin and multivitamin-supplemented cobalamin

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Concurrent Use with Other NNMT Inhibitors or Methylation Modulators Combining with supplements or drugs that also inhibit NNMT or alter methylation (e.g., SAMe , niacin , methylfolate , resveratrol ) could lead to: Excess NAD accumulation Methyl donor depletion Unpredictable metabolic effects Use caution and monitor methylation-related pathways if stacking 3