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The clinical course of MTC is highly variable and unpredictable, ranging from indolent to highly aggressive, depending on multiple factors

(I) HEK293 cells were transfected with the expression plasmid of Flag-tagged TLR4, lysed and treated with GST-HBeAg, and then incubated with glutathione beads for the pull-down experiment

The results revealed a significant increase in the expression levels of KIM-1, a biomarker of renal tubular injury during AKI, whereas the expression levels of GSTT1 and GSTM1 were markedly decreased ( Figure 2 )