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We first assessed the ability of entrectinib to cross the bloodbrain barrier and found that systemic entrectinib (120 mg kg 1 , oral administration) reduced pharmacodynamic markers of TrkB signalling, including TrkB phosphorylation and downstream ERK phosphorylation in brain tissue (Extended Data Fig

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Medications: Some medications, such as diuretics, can lead to dehydration and electrolyte imbalances, increasing the risk of muscle spasms

Neurochem Res 48:22412252