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134 Mutant IDH-targeted therapy and a number of important recent pre-clinical and clinical studies in IDH-mutant solid tumors have been extensively reviewed elsewhere, 147 and listed in Table 2

In cellular and mouse PD models, melatonin decreased the polarization of microglia to M1 and increased the anti-inflammatory M2 through upregulation of its ROR receptors that were downregulated with PD induction [389]