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Similarly, serum proteomic analyses from the AGES-Reykjavik/AGESII cohort identified several candidate protein predictors of type 2 diabetes (IGF-binding protein 2 [IGFBP2], apolipoprotein M [APOM], inhibin C chain [INHBC] and growth hormone receptor [GHR]), many of which are implicated in insulin signalling and metabolic stress pathways [25]