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People can reduce their risk of liver damage by taking the following precautions: taking no more than the maximum daily dose of 4,000 mg, or 650 to 1,000mgevery 4 to 6 hours for adults checking other medications to see if they contain acetaminophen taking only one acetaminophen-containing product at a time Acetaminophen overdose can cause acute liver damage, failure, and death in the most severe cases

Using microsomes from rats fed a vitamin E deficient diet, vitamin E was shown to be rquired for inhibition