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Future efforts should be directed toward developing detection techniques of ferroptosis in vivo and organizing large, randomized clinical trials of anti-ferroptotic drugs in early and late stages of AD progression

The GCLC floxed X CaMKII-Cre mouse was named here as GCLC-KO for the sake of convenience

In this context, TAMs, through their privileged control of iron flux and redox signalling, can orchestrate whether ferroptotic stress becomes tumor-eradicating or merely adaptive [16]