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The first one is folic acid

217 The use of a specific cell line to quantify the activation of the redox-sensitive transcription factor, nuclear factor (erythroid-derived 2)-like 2 (Nrf2), allowed to demonstrate that methotrexate also reduces the activation of the Nrf2-dependent intracellular redox signalling pathway

MLH1 mutations are also associated with increased rates of translesion synthesis (TLS), the process whereby DNA is replicated (by a peculiar class of polymerases) in spite of unrepaired lesions

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