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As IC/BPS might be multifactorial, future research should target different implicated pathways simultaneously and study the role of reactive oxygen species as a root cause in IC/BPS

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In addition, members of the SLC superfamily, the largest family of membrane transporters, including SLC22A4 (OCTN1) and SLC18B1 (VPAT), have been demonstrated to play a key role in the transport of polyamines [286, 287]