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26, 19661975 10.1161/01.ATV.0000232525.65682.a2 [DOI] [PubMed] [Google Scholar] Dermietzel R., Krause D., Kremer M., Wang C., Stevenson B

The C677T variant specifically results in a 30-70% reduction in enzyme activity, likely due to the fact that the alanine to valine amino acid change makes the overall enzyme more heat-sensitive

ngz DF, Bozkurt DS, Balli U, Avci B, Durmu?lar MC, et al

Thus, we hypothesized that GSH depletion enhances the oxidation of key lipogenic factors, rendering them dysfunctional and targeting them for degradation