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Subsequently, the formation and bioavailability of 5-(3,4-dihydroxyphenyl)--valerolactone after intake of Pycnogenol has been demonstrated for human plasma ( ( 6.2 Systemic metabolism: conjugation and deconjugation Dietary polyphenols and microbial metabolites of procyanidins typically undergo a phase II metabolism in enterocytes and liver cells to form glucuronic acid, sulfate, and methyl conjugates (Figure 3) ( After intake of Pycnogenol , phase II conjugates of constituents and metabolites were present in plasma / serum samples (Table 3), followed by caffeic acid with 80%

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It may present with abdominal pain, nausea, vomiting and constipation

Are there instances where your vertigo symptoms seem to coincide with periods of irritability or mood changes, and have you ever explored the potential link to your vitamin B12 levels