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Primary & Secondary Bile Acids: Thyroid hormones help to regulate the rate of bile acid synthesis as well as flow of bile acids from liver, into gallbladder, and into the intestinal tract Secondary bile acids, initially triggered by thyroid hormones, impact energy metabolism by influencing insulin sensitivity and thus blood sugar regulation as well as activating D2 (the T4 to T3 enzyme)

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J Food Compos Anal 107:104367 Dare A, Channa ML, Nadar A (2022) L-ergothioneine

SAMe clinical efficacy is demonstrated in multiple clinical studies such as AD and depression