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10.3233/CH-170326 Clin

After absorption, the substance undergoes conjugation by liver enzymes such as UDP-glucuronosyltransferases (UGTs) and sulphotransferases (SULTs), forming inactive metabolites that further reduce its plasma concentration and limit its distribution to target tissues [53]

Activation of the UPR generally serves as a readout for ER stress, but it is not clear what diminished ER stress implies in terms of an actual accumulation of unfolded proteins, particularly because some stressors, such as palmitate loading, activate the UPR apparently independent of the protein folding process (Volmer et al., 2013)

Hosios, A