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Figure A: Design and subgrouping of the study cohort Figure B: Brief overview of key findings Disclosures: Simon Schophaus: Nothing to Disclose, Paul-Henry Koop: Nothing to Disclose, Jan Clusmann: Nothing to Disclose, Kai Markus Schneider: Nothing to Disclose, Carolin Victoria Schneider: Nothing to Disclose 1158 MASLD AND METALD: THE AMOUNT OF LIVER FAT AND NUMBER OF CARDIOMETABOLIC RISK FACTORS IN RELATION TO THE RISK OF TYPE 2 DIABETES AND CARDIOVASCULAR DISEASE Gabrielle Alblas 1 Jeroen van der Velde 1 Maarten Tushuizen 1 Wouter Jukema 1 Hildo Lamb 1 Frits Rosendaal 1 Bart van Hoek 1 Rene de Mutsert 1 Minneke Coenraad 1 , 1 Leiden University Medical Center Background: Metabolic dysfunction associated steatotic liver disease (MASLD) and metabolic alcohol-associated liver disease (MetALD), defined as the presence of liver fat in combination with at least one of five cardiometabolic risk factors and alcohol consumption of maximum 50 gram/day for women and 60 gram/day for men, is associated with an increased risk of type 2 diabetes and cardiovascular diseases

Both compounds are evaluated for their interaction with intracellular signaling networks and peptide-mediated communication pathways

Mir-183 inhibits the viability, migration and invasion of epithelium on adenomyosis via targeting MMP-9