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Engineering protein-based therapeutics through structural and chemical design

The involvement of individual P450s in the metabolism of a given drug may be screened in vitro by means of selective functional markers, selective chemical P450 inhibitors, and P450 antibodies

The thiol group in Cys contains an electron-rich sulfur atom, which, due to its d -orbital properties, can adopt multiple oxidation states

Preclinical findings demonstrate that systemic inflammation induced by maternal obesity and GDM leads to an increased release of maternal proinflammatory cytokines that cross the placenta and alter the fetal development of neural pathways that regulate behavior [69]