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2.7.1 Basic science research The three specific sensor proteins of ER stress are activating transcription factor 6 (ATF6), inositol requiring enzyme 1 (IRE1), and eukaryotic pancreatic ER kinase (PKR)like ER kinase (PERK): each one activates subsets of effector genes comprising ATF4, caspase-12, CHOP, bcl, and NF-B

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Consistent with reduction of thyroid microvasculatures, blood perfusion of 2000-kDa fluorescein-lysinated dextran was also significantly decreased in thyroid, but not decreased in kidney and skeletal muscles (Supplementary Fig