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(2023) Phase 2 CagriSema combination, Lancet Novo Nordisk REDEFINE 1 Phase 3 results (2025) European Medicines Agency MHRA Medically reviewed by Mohammed Lakhi Superintendent Pharmacist

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Among CagriSema-treated participants, 73.5% achieved HbA1c of 6.5% or below compared to 15.9% with placebo, demonstrating remarkable dual efficacy for both weight and glycemic endpoints

Cagrilintide, a long-acting human amylin analogue, exerts both central and peripheral effects by enhancing satiety, delaying gastric emptying, and modulating postprandial glucagon secretion, whereas semaglutide acts on GLP-1 receptors in the central nervous system and peripheral tissues to regulate appetite, glycemic control, and energy balance