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Abstract Background Serine Hydroxymethyltransferase 1 and 2 (SHMT1/2), as key enzymes in folate metabolism, regulate diverse physiological processes through one-carbon metabolism, including nucleotide biosynthesis, methylation reactions, and redox homeostasis

Despite challenges in achieving consistent BBB penetration, several nanoparticle types, such as lipid- and polymer-based nanoparticles, show strong translational potential

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