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The juxtamembrane region, especially the phosphorylated tyrosine at position 972 in the NPEY motif of IR has been shown to be important for IRS and Shc recruitment 22,23

Also, the delay of relapse upon UAMC-3203 treatment was higher in female mice compared to male littermates (Fig

10.1039/9781849732666-00247 13 CoccoR.StenbergG.DraganiB.PrincipeD

Background of Mitochondrial Biology and Leigh Syndrome Basics of Mitochondria Mitochondria are key organelles that are critical to normal cell and organ function and serve an essential role in maintaining metabolic homeostasis through the production of energy in the form of Adenosine Triphosphate (ATP) (Graeber and Muller, 1998