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Sener G, Sehirli O, Ipci Y, Cetinel S, Cikler E, Gedik N, Alican I

The human dopamine transporter (hDAT) contains a high-affinity, extracellular, and allosteric Zn 2+ (zinc ion) binding site which, upon zinc binding, inhibits dopamine reuptake, inhibits amphetamine-induced hDAT internalization, and amplifies amphetamine-induced dopamine efflux

Effective treatments for quitting include varenicline, bupropion, and nicotine replacement therapy (which includes patches and gum)

Read More The FDA authorized 20 Zyn nicotine pouches, including 10 flavored products, despite concerns from health experts over increased youth use