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132 Compositional expression of HIF1 also resulted in diminished immunostimulatory capacity of DCs, showing an increase in inhibitory mediators including IL10, inducible nitric oxide synthase and vascular endothelial growth factor (VEGF), which associated with a reduction in their ability to drive effector CD8 + T cell functions

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Moreover, the interaction between Bax and Drp-1 has been involved in APAP hepatotoxicity by facilitating mitochondrial fission, which in turn can initiate downstream events, including opening of the MTP