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291,292 Hypoxia-driven Notch activation further promotes tumor progression by increasing the expression of TRPC6, which stimulates NFAT activity and GBM cell proliferation

Although the study was cross-sectional and limited by modest sample size and potential confounding factors (e.g., unmeasured physical activity levels, inflammatory status), it demonstrates how MRS-based creatine profiling could be integrated into multi-parametric diagnostic frameworks

The advent of high-resolution mass spectrometry and sophisticated computational tools has revolutionized our ability to discover and characterize PTMs, revealing over 500 distinct modifications that play crucial roles in virtually every cellular process and human disease 1

10.1016/j.bbamcr.2012.05.002 95 FassoneE.RahmanS