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Nevertheless, a significant number of biomarker-based studies, cell/ in vitro and animal studies did indicate that e-cigarette exposure can result in oxidative stress, cellular apoptosis, DNA damage, genotoxicity, and tumor growth (Figure 2, and Supplementary file Materials 2 and 3), all of which can potentially increase risk of developing lung cancer or progression of any cancer

DOI: 10.1037/0022-3514.39.3.472 [6] Lee C, Cho B, Yang Q, et al

In the Caribbean, Mexico and Central and South America, early forms of cigarettes - including smoking reeds or cigars - were the most common smoking tools

[2] If you cant figure out how to remove the lid or cover, consult the owners manual