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In summary, we collected approximately 453,000 valid daily records from about 1,610 monitors in North America, approximately 567,000 valid daily records from about 2,010 stations in Europe, approximately 612,000 valid daily records from about 1,720 stations in China, as well as approximately 68,000 valid daily records from about 850 stations in other regions for the year 2023

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In HNC, alcohol-related signatures were predominantly observed in patients reporting both alcohol and tobacco consumption, consistent with epidemiological evidence showing a synergistic effect between these two factors on disease risk 9,42