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Within hepatocytes, silymarin shows a high affinity for membrane-bound and nuclear receptors, including PPAR- and CAR/PXR, by enhancing the expression of hepatic detoxification enzymes and improving xenobiotic clearance (Figure 3a) and inhibition of NF-B (Figure 3b), promoting antioxidant defence

Most clinicians use cycled protocols (8 to 12 weeks on, then a break) rather than continuous year-round dosing

This phosphorylation serves as a physiological brake that directly inhibits RIPK1 kinase activity in response to TNF, and prevents TNF-induced RIPK1 kinase-dependent cell death