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These results imply that active glycolysis and OXPHOS are the main sources of energy in circulating HIV infected cells 40,66,67

To verify this result, we assessed the selective sensitivity of VRK2-KO cells (CFPAC-1 cells and SW1990 cells) to APR-017 or LCS3 by employing colony formation assays

This microbial dysregulation additionally predisposes to nephrolithiasis through oxalate metabolism perturbations, manifesting as augmented urinary oxalate excretion consequent to Bifidobacterium depletion and Bacteroides dominance (Cabaa et al., 2024)