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[DOI] [PMC free article] [PubMed] [Google Scholar] 70.Banerjee A, Koziol-White C, Panettieri R., Jr P38 MAPK inhibitors, IKK2 inhibitors, and TNF inhibitors in COPD

Under hypoxic conditions, nuclear-translocated HIF-1 heterodimerizes with HIF-1 to transcriptionally activate downstream effectorsincluding endothelin-1, glucose transporter 1, and VEGFthat collectively mediate pulmonary vascular metabolic reprogramming, hyperproliferation, vasoconstriction, and angiogenesis, all hallmark features of PH pathogenesis (Albanese et al

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