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Role of NLRP3 inflammasome/caspase 1 signaling pathway in cyclophosphamide-induced ovarian injury Inflammasomes, which are multiprotein complexes, assemble in the cytoplasm and are triggered by many endogenous and exogenous stimuli, including ROS and DAMPs

There is large evidence that HGF can mediate neuroinflammation in the context of neurodegenerative autoimmune diseases such as multiple sclerosis (MS), leading to an indirect effect on the immune system

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The T-cell receptor (TCR) is a specific receptor present on the surface of T cells that initiates first transduction signals by specifically recognizing and binding antigenic peptides presented by the major histocompatibility complex (MHC) on the surface of APCs, thereby inducing T-cell activation and performing adaptive immune functions [84]