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A total of 1150 significantly differential metabolites were identified between the HN and LN groups, such as cotinine, NNAL-N-glucuronide, and 11-dehydrothromboxane-B2, which were significantly enriched in some metabolism-related pathways, such as caffeine metabolism, arachidonic acid metabolism, arginine biosynthesis, and arginine and proline metabolism, as well as several disease-related signaling pathways, such as cGMP-PKG signaling pathway, AMPK signaling pathway, mTOR signaling pathway, and Parkinsons disease

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The dirty cloth sold for $5,300, with proceeds going to hunger charity USA Harvest

Since the 1990s, water pipe smoking has spread among new populations and demographics to include college students and young people in the United States, Brazil, Western European and Southern African countries