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& Kirk, G

[3] It says there are health concerns associated with e-cigarettes, and that the devices may make smoking mainstream again, particularly among Hong Kong youth

Furthermore, smokers face a significantly heightened risk of developing coronary heart disease (CHD), a condition in which plaque builds up inside the coronary arteries, impeding blood flow to the heart muscle

CS-induced oxidative stress is responsible for altered cellular metabolism, including increased infiltrating immune cells, pro-inflammatory cytokine production, proteaseantiprotease imbalance, lipid peroxidation, apoptosis, upregulation of unfolded protein response (UPR), and protein misfolding