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Concomitant use of ibuprofen with other NSAIDs, oral corticosteroids, aspirin, anticoagulants, selective serotonin reuptake inhibitors (SSRIs), or serotonin and norepinephrine reuptake inhibitors (SNRIs) can also increase the risk

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Furthermore, the advent of new and more sensitive chromatographic analytical techniques has allowed the Food and Drug Administration (FDA) to update the number of different substances released by the combustion of tobacco, bringing them to over 7 thousand 2 , some of which have irritant properties (e.g