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While aspartate is a substrate for both purine and pyrimidine biosynthesis (both of which are required for cell proliferation) we propose that succinate-mediated ATCase inhibition leads to a disproportionate effect on pyrimidine synthesis, which emerges as the superseding metabolic defect following SDH loss in contexts where pyrimidines cannot otherwise be salvaged

The study revealed that the seroprevalence of HSV-1 IgG was higher among hookah and cigarette smokers compared to those who smoked cigarettes or hookah exclusively

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The strength of the tobacco is also affected by whether the tobacco is washed, that is, whether it washed with water during the making of the blend