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While the review uncovered no substantial evidence of significant adverse effects, it's important to note that most studies tracked participants for a period ranging from six to twelve months, leaving a gap in data concerning potential long-term consequences

Additionally, CTP reconfirms in the final rule its support of reducing reliance on animal testing where adequate and scientifically valid NAMs can be substituted ( CTPs flexibility with considering the use of NAMs is representative of broader initiatives at FDA that have been ongoing for more than a decade

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