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While sub-chronic exposure to PG/nicotine promote nAChR7-dependent increased levels of different cytokines and chemokines in the bronchoalveolar lavage fluid (BALF) such as IL-1, IL-2, IL-9, interferon (IFN), granulocyte-macrophage colony-stimulating factor (GM-CSF), monocyte chemoattractant protein-1 (MCP-1/CCL2) and regulated on activation, normal T cell expressed and secreted (RANTES/CCL5), the enhanced levels of IL-1, IL-5 and TNF were nAChR7 independent

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A number of females expressed the view that RYO cigarettes are more natural not just because of the tobacco being less adulterated, but as they are hand-made: It feels less processed even the filter, I prefer smoking from a filter [I inserted] myself rather it all being connected I dont know whats in tobacco essentially but because Im putting that in a cigarette myself and Im seeing theres no additives or anything like that youve made it yourself When I buy it, I take it out of the packet and its almost like you can taste the other stuff thats in there (FG8, 25-35F)

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