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The number of high frequency cells (HFCs) for each subject was determined as the proportion of metaphases whose SCE frequency exceeds the 95th percentile of the SCE distribution in the NE group, which was defined as those with a count of 14 or more SCEs

Smoking rates have reduced by two-thirds since the first year of No Smoking Day 40 years ago, but smoking is still the single largest preventable cause of death in England - estimated to account for 64,000 deaths annually

The sweetness is understated rather than forward, and the smoke is so mild it is nearly impossible to make harsh